JVAC
21162
S0264-410X(19)31064-3
10.1016/j.vaccine.2019.08.014
The Authors
Short communication
A mid-term estimate of 2018/2019 vaccine effectiveness to prevent laboratory confirmed A(H1N1)pdm09 and A(H3N2) influenza cases in Sicily (Italy)
Claudio
Costantino
a
⁎
claudio.costantino01@unipa.it
Vincenzo
Restivo
a
Emanuele
Amodio
a
Giuseppina Maria Elena
Colomba
b
Francesco
Vitale
a
b
Fabio
Tramuto
a
b
a
Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties “G. D'Alessandro”, Via del Vespro 133, 90127, University of Palermo, Palermo, Italy
Department of Health Promotion Sciences
Maternal and Infant Care
Internal Medicine and Medical Specialties “G. D'Alessandro”
Via del Vespro 133
90127
University of Palermo
Palermo
Italy
Department of Health Promotion, Mother to Child Care, Internal and Specialist Medicine “G. D'Alessandro”, Via del Vespro 133, 90127, University of Palermo, Palermo, Italy
b
Regional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit – Via del Vespro 133, 90127, University Hospital “Paolo Giaccone”, Palermo, Italy
Regional Reference Laboratory for Molecular Surveillance of Influenza
Clinical Epidemiology Unit – Via del Vespro 133
90127
University Hospital “Paolo Giaccone”
Palermo
Italy
Regional Reference Laboratory for Molecular Surveillance of Influenza, Clinical Epidemiology Unit – Via del Vespro 133, 90127, University Hospital “Paolo Giaccone”, Palermo, Italy
⁎
Corresponding author at: Via del Vespro n 133, 90127 Palermo, Italy.
Via del Vespro n 133
90127 Palermo
Italy
Abstract
Influenza season started in Italy during the month of October 2018, approaching the epidemic peak in January 2019. This report aim to explore the mid-term virologic surveillance data of the 2018–2019 influenza season in Sicily and to estimate the effectiveness of seasonal influenza vaccine (VE) against A(H1N1)pdm09 and A(H3N2) influenza viruses. A test-negative design was used to evaluate influenza VE.
In Sicily, almost all influenza infections were sustained by influenza type A viruses, of which 62.3% were A(H3N2) and 36.3% A(H1N1)pdm09. A reduction of laboratory confirmed influenza cases in Sicilian population immunized against influenza were observed. In particular, an overall significant protective values were observed for any influenza A viruses (Adj-VE = 44.0%; 95%CI: 11.2–64.7%), especially among 15–64 years old age group (Adj-VE = 59.5%; 95%CI: 0.03–83.1) and among the elderly (Adj-VE = 73.6%; 95% CI: 29.4–90.2).
Keywords
Influenza vaccine effectiveness
Surveillance network
Laboratory confirmed cases
Influenza epidemic
Influenza viruses
Test-negative design
KBJ00000000012181
2020-01-30T01:49:12
S300.1
S300
S0264-410X(19)31064-3
10.1016/j.vaccine.2019.08.014
JVAC
0264-410X
21162
SCO
NON-CRC
UNLIMITED
CRUI
2019-08-16T20:51:09Z
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