SLEEP
3611
S1389-9457(18)30017-0
10.1016/j.sleep.2018.01.005
The Author(s)
Original Article
Childhood sleep and adolescent chronic fatigue syndrome (CFS/ME): evidence of associations in a UK birth cohort
Simon M.
Collin
a
b
Tom
Norris
c
Paul
Gringras
d
Peter S.
Blair
b
Kate
Tilling
b
Esther
Crawley
a
b
∗
esther.crawley@bristol.ac.uk
a
Centre for Child and Adolescent Health, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK
Centre for Child and Adolescent Health
University of Bristol
Oakfield House, Oakfield Grove
Bristol
BS8 2BN
UK
b
Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
Bristol Medical School
University of Bristol
Canynge Hall, 39 Whatley Road
Bristol
BS8 2PS
UK
c
Department of Health Sciences, College of Medicine, Biological Sciences and Psychology, University of Leicester, Centre for Medicine, University Road, Leicester, LE1 7RH, UK
Department of Health Sciences
College of Medicine
Biological Sciences and Psychology
University of Leicester
Centre for Medicine
University Road
Leicester
LE1 7RH
UK
d
Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK
Evelina London Children's Hospital
Guy's and St Thomas' NHS Foundation Trust
Westminster Bridge Road
London
SE1 7EH
UK
∗
Corresponding author. Centre for Child and Adolescent Health, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Centre for Child and Adolescent Health
University of Bristol
Oakfield House, Oakfield Grove
Bristol
BS8 2BN
UK
Abstract
Objective/Background
Sleep abnormalities are characteristic of chronic fatigue syndrome (CFS, also known as ‘ME’), however it is unknown whether sleep might be a causal risk factor for CFS/ME.
Patients/Methods
We analysed data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. We describe sleep patterns of children aged 6 months to 11 years, who were subsequently classified as having (or not having) ‘chronic disabling fatigue’ (CDF, a proxy for CFS/ME) between the ages 13 and 18 years, and we investigated the associations of sleep duration at age nine years with CDF at age 13 years, as well as sleep duration at age 11 years with CDF at age 16 years.
Results
Children who had CDF during adolescence had shorter night-time sleep duration from 6 months to 11 years of age, and there was strong evidence that difficulties in going to sleep were more common in children who subsequently developed CDF. The odds of CDF at age 13 years were 39% lower (odds ratio (OR) = 0.61, 95% CI = 0.43, 0.88) for each additional hour of night-time sleep at age nine years, and the odds of CDF at age 16 years were 51% lower (OR = 0.49, 95% CI = 0.34, 0.70) for each additional hour of night-time sleep at age 11 years. Mean night-time sleep duration at age nine years was 13.9 (95% CI = 3.75, 24.0) minutes shorter among children who developed CDF at age 13 years, and sleep duration at age 11 years was 18.7 (95% CI = 9.08, 28.4) minutes shorter among children who developed CDF at age 16 (compared with children who did not develop CDF at 13 and 16 years, respectively).
Conclusions
Children who develop chronic disabling fatigue in adolescence have shorter night-time sleep duration throughout early childhood, suggesting that sleep abnormalities may have a causal role in CFS/ME or that sleep abnormalities and CFS/ME are associated with a common pathophysiological cause.
Highlights
•
Adolescents who develop chronic disabling fatigue (CDF) have shorter nighttime sleep duration throughout early childhood.
•
For each additional hour of nighttime sleep at age nine, the odds of CDF at age 13 were 40% lower. For each additional hour of nighttime sleep at age 11, the odds of CDF at age 16 were 50% lower.
•
Sleep abnormalities may have a causal role in CFS/ME, or sleep abnormalities and CFS/ME are related to a common pathophysiological cause.
Keywords
Paediatric
Adolescence
Chronic fatigue syndrome
CFS/ME
Sleep
ALSPAC
KBJ00000000011944
2019-12-23T18:52:20
S300.2
S300
S1389-9457(18)30017-0
10.1016/j.sleep.2018.01.005
SLEEP
1389-9457
3611
FLA
NON-CRC
UNLIMITED
MRCUKPP
2018-01-31T15:51:29Z
13899457/v46sC/S1389945718300170/main.xml
105768
MAIN
JA 5.5.0 ARTICLE
FULL-TEXT
13899457/v46sC/S1389945718300170/main.assets/gr1.sml
8054
IMAGE-THUMBNAIL
13899457/v46sC/S1389945718300170/main.assets/gr2.sml
5304
IMAGE-THUMBNAIL
13899457/v46sC/S1389945718300170/main.assets/gr3.sml
4614
IMAGE-THUMBNAIL
13899457/v46sC/S1389945718300170/main.assets/gr4.sml
5118
IMAGE-THUMBNAIL
13899457/v46sC/S1389945718300170/main.assets/gr5.sml
7347
IMAGE-THUMBNAIL
13899457/v46sC/S1389945718300170/main.assets/gr6.sml
6845
IMAGE-THUMBNAIL
13899457/v46sC/S1389945718300170/main.assets/gr7.sml
6076
IMAGE-THUMBNAIL
13899457/v46sC/S1389945718300170/main.assets/gr1.jpg
81764
IMAGE-DOWNSAMPLED
13899457/v46sC/S1389945718300170/main.assets/gr2.jpg
48741
IMAGE-DOWNSAMPLED
13899457/v46sC/S1389945718300170/main.assets/gr3.jpg
43133
IMAGE-DOWNSAMPLED
13899457/v46sC/S1389945718300170/main.assets/gr4.jpg
44260
IMAGE-DOWNSAMPLED
13899457/v46sC/S1389945718300170/main.assets/gr5.jpg
53322
IMAGE-DOWNSAMPLED
13899457/v46sC/S1389945718300170/main.assets/gr6.jpg
48213
IMAGE-DOWNSAMPLED
13899457/v46sC/S1389945718300170/main.assets/gr7.jpg
58826
IMAGE-DOWNSAMPLED
13899457/v46sC/S1389945718300170/main.assets/mmc4.zip
2658173
APPLICATION
13899457/v46sC/S1389945718300170/main.assets/mmc1.pdf
193640
APPLICATION
13899457/v46sC/S1389945718300170/main.assets/mmc2.pdf
193720
APPLICATION
13899457/v46sC/S1389945718300170/main.assets/mmc3.docx
13190
APPLICATION
13899457/v46sC/S1389945718300170/main.pdf
1943932
MAIN
1.7 6.5
DISTILLED OPTIMIZED BOOKMARKED
13899457/v46sC/S1389945718300170/main.raw
47036
S1389-9457(18)X0005-7
SLEEP
1389-9457
46
C
201806
1
122
S1389-9457(18)30017-0
10.1016/j.sleep.2018.01.005
26
36
main.pdf
PDF
1.7