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Adult Atopic Dermatitis with Comorbid Atopic Disease is Associated with Increased Risk of Infections: A Population-Based Cross-Sectional Study
Narala, Saisindhu
Hata, Tissa R.
text
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Dermatology and therapy
continuing
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Elektronische Wetenschappelijke Tijdschriften
EWTIJ
10.1007/s13555-017-0172-7
urn:nbn:nl:kb-1489064985088
Automatisch gegenereerd op basis van de EWTIJ XML in release 1.5 van het digitaal magazijn.
Springer Healthcare
Cheshire
Adis
13555
10.1007/13555.2190-9172
2193-8210
2190-9172
Dermatology and Therapy
Research, treatment and aesthetic interventions in dermatology
Dermatol Ther (Heidelb)
Medicine & Public Health
Internal Medicine
Dermatology
Plastic Surgery
Oral and Maxillofacial Surgery
Quality of Life Research
SC11
7
7
4
1
1
15
2017
3
3
2017
3
3
2017
3
2017
Springer Healthcare
2017
172
10.1007/s13555-017-0172-7
8
Adult Atopic Dermatitis with Comorbid Atopic Disease is Associated with Increased Risk of Infections: A Population-Based Cross-Sectional Study
Original Research
111
121
2017
1
16
2016
12
15
2017
1
30
The Author(s)
2017
Saisindhu
Narala
sindhunarala@gmail.com
Tissa
R.
Hata
Department of Dermatology
University of California, San Diego
San Diego
CA
USA
Abstract
Introduction
Atopic dermatitis (AD) is related to other atopic diseases asthma and allergic rhinitis. It is known that those with asthma or allergic rhinitis have impaired immune responses that may predispose them to infections. This study sought to determine whether adult AD is associated with systemic infections, and whether association is strengthened in those with AD plus another atopic disease.
Methods
This cross-sectional study obtained information from adults in the 2010 and the 2012 National Health Interview Survey (NHIS). The primary exposure was history of AD without or with an additional atopic disease, asthma or allergic rhinitis. Self-reported systemic infections were the primary outcomes. Survey logistic regression was performed and adjusted odds ratios (aOR) reported.
Results
AD in NHIS 2010 was associated with increased risk of sinusitis [aOR (95% CIs): 1.65 (1.42, 1.91), P < 0.001], head or chest cold [1.31 (1.12, 1.52), P < 0.001], and gastrointestinal illness [2.39 (1.97, 2.89), P < 0.001], and in NHIS 2012, pneumonia/influenza [1.73 (1.54, 1.95), P < 0.001], strep throat/tonsillitis [1.72 (1.54, 1.92), P < 0.001], sinusitis [1.77 (1.54, 2.02), P < 0.001], head or chest cold [1.49 (1.33, 1.67), P < 0.001], and infectious disease [2.66 (2.20, 3.21), P < 0.001]. An increase in atopic disease mirrored an increase in number of infectious outcomes and was statistically significant in the combined dataset (P < 0.001).
Conclusion
The associations between AD and AD plus another atopic disease with systemic infections suggest that an underlying immune defect may be contributing to microbial susceptibility. Further studies are warranted to understand the burden of infectious disease in this population.
Keywords
Allergic rhinitis
Atopic dermatitis
Asthma
Infection
Enhanced content
To view enhanced content for this article go to
http://www.medengine.com/Redeem/C387F0603683BDAA
.
Electronic supplementary material
The online version of this article (doi:
10.1007/s13555-017-0172-7
) contains supplementary material, which is available to authorized users.
Springer Healthcare
Cheshire
Adis
13555
10.1007/13555.2190-9172
2193-8210
2190-9172
Dermatology and Therapy
Research, treatment and aesthetic interventions in dermatology
Dermatol Ther (Heidelb)
Medicine & Public Health
Internal Medicine
Dermatology
Plastic Surgery
Oral and Maxillofacial Surgery
Quality of Life Research
SC11
7
7
4
1
1
15
2017
3
3
2017
3
3
2017
3
2017
Springer Healthcare
2017
172
10.1007/s13555-017-0172-7
8
Adult Atopic Dermatitis with Comorbid Atopic Disease is Associated with Increased Risk of Infections: A Population-Based Cross-Sectional Study
Original Research
111
121
2017
1
16
2016
12
15
2017
1
30
The Author(s)
2017
Saisindhu
Narala
sindhunarala@gmail.com
Tissa
R.
Hata
Department of Dermatology
University of California, San Diego
San Diego
CA
USA
Abstract
Introduction
Atopic dermatitis (AD) is related to other atopic diseases asthma and allergic rhinitis. It is known that those with asthma or allergic rhinitis have impaired immune responses that may predispose them to infections. This study sought to determine whether adult AD is associated with systemic infections, and whether association is strengthened in those with AD plus another atopic disease.
Methods
This cross-sectional study obtained information from adults in the 2010 and the 2012 National Health Interview Survey (NHIS). The primary exposure was history of AD without or with an additional atopic disease, asthma or allergic rhinitis. Self-reported systemic infections were the primary outcomes. Survey logistic regression was performed and adjusted odds ratios (aOR) reported.
Results
AD in NHIS 2010 was associated with increased risk of sinusitis [aOR (95% CIs): 1.65 (1.42, 1.91), P < 0.001], head or chest cold [1.31 (1.12, 1.52), P < 0.001], and gastrointestinal illness [2.39 (1.97, 2.89), P < 0.001], and in NHIS 2012, pneumonia/influenza [1.73 (1.54, 1.95), P < 0.001], strep throat/tonsillitis [1.72 (1.54, 1.92), P < 0.001], sinusitis [1.77 (1.54, 2.02), P < 0.001], head or chest cold [1.49 (1.33, 1.67), P < 0.001], and infectious disease [2.66 (2.20, 3.21), P < 0.001]. An increase in atopic disease mirrored an increase in number of infectious outcomes and was statistically significant in the combined dataset (P < 0.001).
Conclusion
The associations between AD and AD plus another atopic disease with systemic infections suggest that an underlying immune defect may be contributing to microbial susceptibility. Further studies are warranted to understand the burden of infectious disease in this population.
Keywords
Allergic rhinitis
Atopic dermatitis
Asthma
Infection
Enhanced content
To view enhanced content for this article go to
http://www.medengine.com/Redeem/C387F0603683BDAA
.
Electronic supplementary material
The online version of this article (doi:
10.1007/s13555-017-0172-7
) contains supplementary material, which is available to authorized users.
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