PSYN
10437
S0925-4927(15)30079-2
10.1016/j.pscychresns.2015.09.002
Characterising intra- and inter-intrinsic network synchrony in combat-related post-traumatic stress disorder
Benjamin T.
Dunkley
a
b
c
⁎
ben.dunkley@sickkids.ca
Sam M.
Doesburg
a
b
c
d
Rakesh
Jetly
e
Paul A.
Sedge
e
Elizabeth W.
Pang
b
f
Margot J.
Taylor
a
b
c
d
a
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
Department of Diagnostic Imaging, The Hospital for Sick Children
Toronto
Canada
b
Neuroscience & Mental Health Program, The Hospital for Sick Children Research Institute, Toronto, Canada
Neuroscience & Mental Health Program, The Hospital for Sick Children Research Institute
Toronto
Canada
c
Department of Medical Imaging, University of Toronto, Toronto, Canada
Department of Medical Imaging, University of Toronto
Toronto
Canada
d
Department of Psychology, University of Toronto, Toronto, Canada
Department of Psychology, University of Toronto
Toronto
Canada
e
Directorate of Mental Health, Canadian Forces Health Services, Ottawa, Canada
Directorate of Mental Health, Canadian Forces Health Services
Ottawa
Canada
f
Division of Neurology, The Hospital for Sick Children, Toronto, Canada
Division of Neurology, The Hospital for Sick Children
Toronto
Canada
⁎
Corresponding author at: Department of Diagnostic Imaging, 555 University Ave., Toronto, Canada M5G 1X8.
Department of Diagnostic Imaging
555 University Ave.
Toronto
M5G 1X8
Canada
Abstract
Soldiers with post-traumatic stress disorder (PTSD) exhibit elevated gamma-band synchrony in left fronto-temporal cortex, and connectivity measures in these regions correlate with comorbidities and PTSD severity, which suggests increased gamma synchrony is related to symptomology. However, little is known about the role of intrinsic, phase-synchronised networks in the disorder. Using magnetoencephalography (MEG), we characterised spectral connectivity in the default-mode, salience, visual, and attention networks during resting-state in a PTSD population and a trauma-exposed control group. Intrinsic network connectivity was examined in canonical frequency bands. We observed increased inter-network synchronisation in the PTSD group compared with controls in the gamma (30–80Hz) and high-gamma range (80–150Hz). Analyses of connectivity and symptomology revealed that PTSD severity was positively associated with beta synchrony in the ventral-attention-to-salience networks, and gamma synchrony within the salience network, but also negatively correlated with beta synchrony within the visual network. These novel results show that frequency-specific, network-level atypicalities may reflect trauma-related alterations of ongoing functional connectivity, and correlations of beta synchrony in attentional-to-salience and visual networks with PTSD severity suggest complicated network interactions mediate symptoms. These results contribute to accumulating evidence that PTSD is a complicated network-based disorder expressed as altered neural interactions.
Highlights
•
Increased intrinsic inter-network synchronisation in PTSD compared with controls.
•
PTSD severity was associated with synchrony within and between a number of networks.
•
Network atypicalities may reflect trauma-related alterations to connectivity.
•
Evidence suggests PTSD is a network disorder expressed as altered neural interactions.
Keywords
Post-traumatic stress disorder
Soldiers
Magnetoencephalography (MEG)
Intrinsic connectivity networks
Resting-state
Functional connectivity
Oscillations
Neural synchrony
KBJ00000000003145
2015-10-30T20:49:26
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S0925-4927(15)30079-2
10.1016/j.pscychresns.2015.09.002
PSYN
0925-4927
10437
FLA
NON-CRC
UNLIMITED
NONE
2015-09-12T14:01:46Z
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